郭瑾烨;黄艳;曹玲华;

• 1:新疆大学化学化工学院

摘要(Abstract)：

制备了两种胍基化试剂:N-硝基-1-(3,5-二甲基吡唑)脒1,N,N-二叔丁氧羰基硫脲2,将一系列胺类化合物分别与两种胍基化试剂作用,制得新化合物1a-1j,2a-2j,并对两种胍基化试剂的性能进行了比较.所有新化合物的结构均经IR,1HNMR和元素分析证实.

关键词(KeyWords)： 胍基化试剂;制备;应用

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(No.20462006);; 新疆植物资源与天然产物化学重点实验室资助项目

作者(Authors): 郭瑾烨;黄艳;曹玲华;

参考文献(References)：

• [1]Nirmal K P,Hitoshi Ube,Masahiro T.Aza-Henry reaction of ketimines catalyzed by guanidine and phosphazene bases[J].Tetrahedron Lett.2007,48,8700-8703.
• [2]Ye Weiping,Xu Junye,Tan Chin-Tong,et al.1,5,7-Triazabicyclo[4.4.0]dec-5-ene(TBD)catalyzed Michael reactions[J].Tetrahedron Lett.2005,46,6875-6878.
• [3]Akbar H,Afsaneh S K,Roohollah K S.Guanidine hydrochloride:An active and simple catalyst for Strecker type reaction[J].Journal of Molecular Catalysis A:Chemical2007,271,142-144.
• [4]Gubareva L V,Kaiser L,Hayden F G.Inffuenza virus neuraminidase inhibitors[J].The Lancet2000,355,827-835.
• [5]Reitz A B,Tuman R W,Marchione C S,et al.Carbohydrate biguanides as potential Hypoglycemic agents[J].J.Med.Chem.1989,32,2110-2116.
• [6]Baker T J,Luedtke N W,Goodman M,et al.Synthesis and anti-HIV activity of guanidinoglycosides[J].J.Org.Chem.2000,65,9054-9058.
• [7]Luedtke N W,Baker T J,Goodman M,et al.Guanidinoglycosides:a novel family of RNA ligands[J].J.Am.Chem.Soc.2000,122,12035-12036.
• [8]Jeong J H,Murray B W,Takayama S,et al.Cyclic guanidino-sugars with low pKa as transition-state analog inhibitors of glycosidases:Neutral instead of charged species are the active forms[J].J.Am.Chem.Soc.1996,118,4227-4234.
• [9]曹玉娟,高海翔,鲁润华.胍类化合物的合成进展[J].合成化学2003,23(2):1-5.
• [10]Castillo M,Joel A,Golding B T.Optimisation of the Synthesis of Guanidines from Amines via Nitroguanidines Using 3,5-Dimethyl-N-nitro-1H-pyrazole-1-carboxamidine[J].Synthesis2004,3(10):1655-1663.
• [11]Catherine L,Joanne L,Soo Y Ko.The HgCl2-Promoted Guanylation Reaction:The Scope and Limitations[J].Tetrahedron.1997,53,5291-5304.
• [12]张雅文,周华,刘晓峰.4-(4-甲基苯氧基)苄胺的合成[J].应用化学,2003,1:98-99.
• [13]李在国.有机中间体制备[M].北京:化学工业出版社,第二版.